Regulation of Lymphocyte Responses In Vitro: Potentiation and Inhibition of Rat Lymphocyte Responses to Antigen and Mitogens by Cytochalasin B

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Regulation of lymphocyte responses in vitro: potentiation and inhibition of rat lymphocyte responses to antigen and mitogens by cytochalasin B.

Cytochalasin B, at concentration between 0.02 and 0.2 mug/ml, was slightly stimulatory to lymph-node cells from normal rats and greatly potentiated their response to phytohemagglutinin and low concentrations of concanavalin A (mitogens for thymus-derived lymphocytes); it also potentiated the response of thymocytes to phytohemagglutinin. The response of lymphnode cells to lipopolysaccharide endo...

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Regulation of Lymphocyte Responses in Vitro

DNA synthesis of normal rat spleen cells in response to endotoxin increases markedly if adherent cells are first removed from the cell suspension. Addition of small numbers of purified macrophages to the cultures restores the response to a low level. T-deprived cells show these effects in very much lesser degree. Large numbers of macrophages completely suppress the response of both normal and T...

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Inhibition of lymphocyte proliferative responses by ribavirin.

When added to cultures of human peripheral blood lymphocytes, ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) inhibited antigen- and mitogen-induced proliferative responses as determined by [3H]thymidine incorporation. Dose-dependent suppressive effects were obtained when concentrations of 5 to 60 microgram of ribavirin per ml were added at culture initiation or up to 96 h there...

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Kinetics of Primary and Memory Cytotoxic T Lymphocyte Responses to Herpes Simplex Virus 1 Infection: Granzyme B Mediated CTL Activity

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1972

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.69.11.3251